Anybody want a Corona?

[blueviper]

[verb_to_trust]

the messaging could be stronger. takes a lot to combat lack of common sense and selfishness.

People are so eager to point the finger and blame. It's not helpful.

easy to do to the snowflakes who can't handle a bit of fabric over their mouth

I'm sure if you just virtue signal to them as hard as you possibly can they will start to see things your way.

It’s science, caveboy.

Do you believe abstinence only sex education works Spike?

I thought you were concerned with messaging?

Where are you going with this? Do you even know?

Your kid is going to do coke just to spite you someday

[Peeps]

Your kid is going to do coke just to sprite you someday

[96583UP]

what a fucking idiot

Report: Trump administration declined Pfizer offer for more vaccine doses

Administration officials turned down an offer from Pfizer this summer to secure additional doses of its vaccine, the New York Times has reported.

The Times reports:

Trump administration officials passed when Pfizer offered in late summer to sell the U.S. government additional doses of its Covid-19 vaccine, according to people familiar with the matter. Now Pfizer may not be able provide more of its vaccine to the United States until next June because of its commitments to other countries, they said.

The US is expected to authorize the two-dose treatment from Pfizer and BioNTech this week and has bought up enough of the vaccine for 50m Americans. Meanwhile the European Union has secured 200m doses and Britan plans to begin vaccinations on Tuesday using the Pfizer treatment.

[B]

I’m not sure what people are confused about. Yea there was a brief moment questioning the validity of masks early on but for damn near 8 months now it’s been “wear masks, don’t gather”

It’s not the messaging. It’s people 1) not caring and 2) being burnt out on it.

There's lots to be confused about. What are essential services? What does border closures mean? If bars and restaurants are allowed to be open, does that mean they're safe? Does the government want us to follow their legislated rules or other non-legislated rules (stay home, keep as small a bubble as possible)? If business activity X is deemed safe and legal, why isn't business activity Y that seems to have the same risk profile? Are masks required outside? Are socially distanced get togethers safe when outdoors? When indoors?

I mean, you're right, every state, county, city, and neighborhood have their own rules.

"If business activity X is deemed safe and legal, why isn't business activity Y that seems to have the same risk profile?"

This is the question that drives me bonkers. NO business is safe. Some are safer than others. Some are more essential than others. I've seen people ask why grocery stores can be open but record stores can't. Because you won't starve to death in the absence of records, asshole.

Weren't you at a record store last week thirsting around for that Painted Shield record?

Record stores are open where I am. I'm only human, verb!

[verb_to_trust]

what a fucking idiot

Report: Trump administration declined Pfizer offer for more vaccine doses

Administration officials turned down an offer from Pfizer this summer to secure additional doses of its vaccine, the New York Times has reported.

The Times reports:

Trump administration officials passed when Pfizer offered in late summer to sell the U.S. government additional doses of its Covid-19 vaccine, according to people familiar with the matter. Now Pfizer may not be able provide more of its vaccine to the United States until next June because of its commitments to other countries, they said.

The US is expected to authorize the two-dose treatment from Pfizer and BioNTech this week and has bought up enough of the vaccine for 50m Americans. Meanwhile the European Union has secured 200m doses and Britan plans to begin vaccinations on Tuesday using the Pfizer treatment.

There will be other vaccines. Probably ones that don't require the level of cold storage Pfizer does. It's not the end of the world.

[verb_to_trust]

I’m not sure what people are confused about. Yea there was a brief moment questioning the validity of masks early on but for damn near 8 months now it’s been “wear masks, don’t gather”

It’s not the messaging. It’s people 1) not caring and 2) being burnt out on it.

There's lots to be confused about. What are essential services? What does border closures mean? If bars and restaurants are allowed to be open, does that mean they're safe? Does the government want us to follow their legislated rules or other non-legislated rules (stay home, keep as small a bubble as possible)? If business activity X is deemed safe and legal, why isn't business activity Y that seems to have the same risk profile? Are masks required outside? Are socially distanced get togethers safe when outdoors? When indoors?

I mean, you're right, every state, county, city, and neighborhood have their own rules.

"If business activity X is deemed safe and legal, why isn't business activity Y that seems to have the same risk profile?"

This is the question that drives me bonkers. NO business is safe. Some are safer than others. Some are more essential than others. I've seen people ask why grocery stores can be open but record stores can't. Because you won't starve to death in the absence of records, asshole.

Weren't you at a record store last week thirsting around for that Painted Shield record?

Record stores are open where I am. I'm only human, verb!

It was basically RMs French Laundry moment.

[spike]

the messaging could be stronger. takes a lot to combat lack of common sense and selfishness.

People are so eager to point the finger and blame. It's not helpful.

easy to do to the snowflakes who can't handle a bit of fabric over their mouth

I'm sure if you just virtue signal to them as hard as you possibly can they will start to see things your way.

It’s science, caveboy.

Do you believe abstinence only sex education works Spike?

I thought you were concerned with messaging?

Where are you going with this? Do you even know?

Your kid is going to do coke just to spite you someday

I doubt it.

[B]

what a fucking idiot

Report: Trump administration declined Pfizer offer for more vaccine doses

Administration officials turned down an offer from Pfizer this summer to secure additional doses of its vaccine, the New York Times has reported.

The Times reports:

Trump administration officials passed when Pfizer offered in late summer to sell the U.S. government additional doses of its Covid-19 vaccine, according to people familiar with the matter. Now Pfizer may not be able provide more of its vaccine to the United States until next June because of its commitments to other countries, they said.

The US is expected to authorize the two-dose treatment from Pfizer and BioNTech this week and has bought up enough of the vaccine for 50m Americans. Meanwhile the European Union has secured 200m doses and Britan plans to begin vaccinations on Tuesday using the Pfizer treatment.

There will be other vaccines. Probably ones that don't require the level of cold storage Pfizer does. It's not the end of the world.

I agree with verb a little here. There are a lot of moving parts here, and there are a lot of potential justifications for making that decision.

[Rob]

How quickly my state went from one of the best, to not so good.

[BurtReynolds]

tennessee seems like a weird outlier

[spike]

i feel like we need to be fairly concerned over this mysterious india outbreak. life comes at you fast in 2020.

[BurtReynolds]

https://www.dailymail.co.uk/news/articl ... ssion=true

[verb_to_trust]

[quote="spike"]i feel like we need to be fairly concerned over this mysterious india outbreak. life comes at you fast in 2020.[/q

This is just going to be reality now. If 2009 swine flu happened now we'd lock back down over that.

[Rob]

i feel like we need to be fairly concerned over this mysterious india outbreak. life comes at you fast in 2020.

This is just going to be reality now. If 2009 swine flu happened now we'd lock back down over that.

We haven't been locked down for the last 6-7 months despite this being way worse than swine flu the entire time.

[Bi_3]

i feel like we need to be fairly concerned over this mysterious india outbreak. life comes at you fast in 2020.

Agree. China isn’t gonna stop releasing this stuff until we are all dead

[Peeps]

take this for what its worth



Today the FDA released Pfizer’s Phase III vaccine trial data. This is big, as this is the first time we, scientists, have seen the data. Pfizer’s report was 92 pages long and the FDA report was 53 pages long. And, yes, I read it all. Here are your cliff notes…

Things are looking good. Well, not just good, they are looking great. This trial was as clean as it can get. There is nothing (big) we didn't expect.

Efficacy.
• We see benefit starting 14 days after the first dose (see Figure). This makes sense because it takes about 2 weeks for the immune system to make sufficient antibody protection after vaccination.
• After the first dose, efficacy was 52%. This is a fantastic for a single dose.
• After your second dose (3 weeks later), efficacy is 95%. We are confident that efficacy ranges from 90-98%.
• Efficacy doesn’t meaningfully differ by age, race/ethnicity, or comorbidity.

Adverse events.
• Overall, the Pfizer vaccination gives more adverse events than the flu vaccination but less than the shingles vaccine.
• The most common solicited adverse reaction (i.e. what we were expecting) were mild to moderate: injection site reactions (84.1%), fatigue (62.9%), headache (55.1%), muscle pain (38.3%), chills (31.9%), joint pain (23.6%), fever (14.2%)
• The chance of getting a serious adverse event was low (<0.5%). A severe event is more likely in the second dose than the first and were less frequent among older adults compared to younger participants.
• An unsolicited (i.e. not expected) adverse event that came up more in the vaccine group was swollen lymph nodes (lymphadenopathy). 64 people in the vaccine group compared to 6 people in the placebo group. This could be related to the vaccine.
• There were 4 people in the vaccine group that got Bell’s palsy (compared to 0 in the placebo group). These cases occurred at 3,
9, 37, and 48 days after vaccination. This isn’t much of a concern because it reflects the same rate of Bell’s palsy in the general population. Something to keep an eye on
• 6 people died during the trial (4 in placebo; 2 in vaccine group). Deaths were NOT related to the vaccine. Mostly related to heart attacks.

There are a few unknowns. From this study, we do not know…
• Duration of protection
• Effectiveness against transmission
• Effectiveness or safety among certain high-risk populations, such as children less than 16 years of age, pregnant and lactating individuals, and immunocompromised individuals. There were just not enough people in the study to make meaningful conclusions. This likely means that the FDA will not approve emergency use for these populations. We will know more on Thursday.
• Benefits of individuals with prior COVID19 infection. But, given there is documented reinfection, the FDA stated that previously infected people could benefit from vaccination.

Translation: This vaccine will likely be approved on Thursday. Which, by the way, will be streaming live. An event that will likely go down in history, albeit a bit boring, scientific, and long

[verb_to_trust]

The vaccine works

[96583UP]

what a fucking idiot

Report: Trump administration declined Pfizer offer for more vaccine doses

Administration officials turned down an offer from Pfizer this summer to secure additional doses of its vaccine, the New York Times has reported.

The Times reports:

Trump administration officials passed when Pfizer offered in late summer to sell the U.S. government additional doses of its Covid-19 vaccine, according to people familiar with the matter. Now Pfizer may not be able provide more of its vaccine to the United States until next June because of its commitments to other countries, they said.

The US is expected to authorize the two-dose treatment from Pfizer and BioNTech this week and has bought up enough of the vaccine for 50m Americans. Meanwhile the European Union has secured 200m doses and Britan plans to begin vaccinations on Tuesday using the Pfizer treatment.

There will be other vaccines. Probably ones that don't require the level of cold storage Pfizer does. It's not the end of the world.

I agree with verb a little here. There are a lot of moving parts here, and there are a lot of potential justifications for making that decision.

well glad i could bring you two youts together

[blueviper]

take this for what its worth



Today the FDA released Pfizer’s Phase III vaccine trial data. This is big, as this is the first time we, scientists, have seen the data. Pfizer’s report was 92 pages long and the FDA report was 53 pages long. And, yes, I read it all. Here are your cliff notes…

Things are looking good. Well, not just good, they are looking great. This trial was as clean as it can get. There is nothing (big) we didn't expect.

Efficacy.
• We see benefit starting 14 days after the first dose (see Figure). This makes sense because it takes about 2 weeks for the immune system to make sufficient antibody protection after vaccination.
• After the first dose, efficacy was 52%. This is a fantastic for a single dose.
• After your second dose (3 weeks later), efficacy is 95%. We are confident that efficacy ranges from 90-98%.
• Efficacy doesn’t meaningfully differ by age, race/ethnicity, or comorbidity.

Adverse events.
• Overall, the Pfizer vaccination gives more adverse events than the flu vaccination but less than the shingles vaccine.
• The most common solicited adverse reaction (i.e. what we were expecting) were mild to moderate: injection site reactions (84.1%), fatigue (62.9%), headache (55.1%), muscle pain (38.3%), chills (31.9%), joint pain (23.6%), fever (14.2%)
• The chance of getting a serious adverse event was low (<0.5%). A severe event is more likely in the second dose than the first and were less frequent among older adults compared to younger participants.
• An unsolicited (i.e. not expected) adverse event that came up more in the vaccine group was swollen lymph nodes (lymphadenopathy). 64 people in the vaccine group compared to 6 people in the placebo group. This could be related to the vaccine.
• There were 4 people in the vaccine group that got Bell’s palsy (compared to 0 in the placebo group). These cases occurred at 3,
9, 37, and 48 days after vaccination. This isn’t much of a concern because it reflects the same rate of Bell’s palsy in the general population. Something to keep an eye on
• 6 people died during the trial (4 in placebo; 2 in vaccine group). Deaths were NOT related to the vaccine. Mostly related to heart attacks.

There are a few unknowns. From this study, we do not know…
• Duration of protection
• Effectiveness against transmission
• Effectiveness or safety among certain high-risk populations, such as children less than 16 years of age, pregnant and lactating individuals, and immunocompromised individuals. There were just not enough people in the study to make meaningful conclusions. This likely means that the FDA will not approve emergency use for these populations. We will know more on Thursday.
• Benefits of individuals with prior COVID19 infection. But, given there is documented reinfection, the FDA stated that previously infected people could benefit from vaccination.

Translation: This vaccine will likely be approved on Thursday. Which, by the way, will be streaming live. An event that will likely go down in history, albeit a bit boring, scientific, and long

Thanks for summarizing for us. Very nice of you.